One-of-a-kind duplex condo residence on one of Tribeca's best blocks boasting a unique history and design, and an impeccable gut-renovation! This special gem is distinctive in every way, boasting 2 expansive stories of loft-like living space bathed in light with triple exposures (south, east and west), a separate duplex studio across the hall that was also finely renovated, a large private storage room in the cellar, common roof deck with garden and planting beds for every unit! VERY low combined monthly expenses! This quintessential primary home and live-work space was transformed by architect David Bers and has received multiple design and architectural awards, incorporating both state-of-the-art technological elements and renewable materials. Among the exhaustive list of impressive features and finishes gracing the exquisite interiors is renewable bamboo; pocket doors; custom lighting; double-paned windows for peace and quiet; custom blackout shades operated by Lutron; transom windows, keypad entry on all doors connected to a virtual doorman; original floors, extensive storage including deep entryway storage, shoe storage, and chic built-ins throughout; fully integrated Sonos speakers; private security; a projector for digital art; and brand new central air. Tasteful custom furniture optimizes style and elegance, maximizes every square inch of space, and can come with the sale. The main level is fabulous for living and entertaining, featuring a 40'-long open great room marked by high beamed ceilings, custom built-ins and wall of south-facing windows. Culinary creations are inspired in the chef's kitchen appointed with thoughtful cabinetry storage, a huge center island, 2 sinks, instant hot water, and high-end appliances including a professional Miele stove, integrated sub-zero refrigerator, 2 dishwashers, and dual wine fridges. Unwind in your primary bedroom retreat presenting custom upholstery for sound protection, hidden cabinetry with electricity for charging devices, a custom dressing room lined with built-outs and shoe closets, spa bath with custom sink and designer fixtures, and heated floors in both the bedroom and spa bath. Also on this floor is a yoga/meditation/tatami room/office, 2nd bedroom, 2nd full bath, powder room, and laundry room with oversized washer and vented-out dryer. A sleek staircase and a separate entrance access the apartment's lower level, a kids' paradise with a homework area/playroom, media room, mini kitchen with microwave for popcorn, plus 3 sunny bedrooms with custom built-in beds, shelving and closets, and a full bath with heated floor - great for sleepovers and movie nights! Masterfully renovated 4S additionally comes with a separate duplex studio down the hall for use as an office, gym, darkroom, etc. It offers double-height ceilings, a large window, Ketra lighting, plumbing and electricity, HVAC, and an upstairs loft. Built in 1940 as a textile warehouse and converted to a boutique condominium in 2001, 16 Desbrosses Street in prime West Tribeca is a 6-story elevator building with a superintendent and beautiful planted rooftop terrace. The coveted location on a quaint cobblestoned block is central to Tribeca and Soho, convenient to Hudson River Park, public transportation, and a wealth of shops and restaurants.